Revolutionary Molecular Solutions
A novel and versatile approach to managing peanut allergies.
Fistoq Development – FISTOQ offers groundbreaking molecular solutions for peanut allergy in the world of agriculture, food processing, and decontamination. Our innovative products improve peanut safety and provide superior protection across industries.
We developed peanut allergen-specific aptamers using in silico computational methods. These aptamers specifically bind to peanut allergens Ara h2 and Ara h1. Our aptamers effectively nautralize crude peanut-induced degranulation in the RBL-2H3 cell line in vitro. Additionally, we found that our aptamers are stable at various temperatures, demonstrating excellent heat stability.
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To further test their application, we introduced these aptamers to peanut plants by watering them with an aptamer solution.
We found that the aptamers were only present in the peanut seeds.
Remarkably, peanuts grown this way did not induce degranulation in the RBL-2H3 cells, indicating that we successfully developed allergy-free peanuts.
Our aptamers also proved beneficial in food processing applications. When mixed with commercial peanut butter, they effectively neutralized the peanut allergens by stably binding to denatured allergenic peanut proteins. Additionally, coating or soaking peanut seeds with these aptamers neutralized the allergenic proteins, preventing degranulation.
We verified that our aptamers are non-immunogenic and can modulate the Th1/Th2 immune response in allergy models. Specifically, they induce Th1 responses while downregulating Th2 responses, which are key markers in the development of allergies. Our aptamers effectively downregulate Th2 cytokines IL-4, IL-5, and IL-13, while inducing Th1 cytokines. Furthermore, we demonstrated that these aptamers are effective both preventatively and therapeutically.
Healthcare – Hospital-grade decontamination
Food Services – Kitchen surfaces, diving areas, food storage, utensils and dishware decontamination
Hospitality – Guest room and common area decontamination
Education – Classroom and playground decontamination
Transportation – Vehicle and station decontamination
Retail – Store surface and product decontamination
Sports and Recreation Facilities -Locker rooms, equipment decontamination
Beauty and Wellness – Salons Spas Decontamination
Office and Workplaces – Workstations and shared equipment dercontamination
Environmental Impact
Biodegradable – FISTOQ molecules break down naturally, leaving no harmful residues
Reduced Chemical Use – FISTOQ decreases reliance on harsh chemical cleaners
Water Conservation – Efficient FISTOQ formulas require less water for decontamination.
Global Reach and Support
North America – Full product line and technical support
Europe – Customized solutions for EU regulations
Asia – Specialized formulas for diverse climates
Africa – Sustainable farming solutions
South America – Food processing and agriculture focus
Australia – Hospitality and healthcare emphasis
FISTOQ Technology
Molecular Engineering – Advanced research creates targeted FISTOQ molecules
Nano-scale Action – FISTOQ works at the microscopic level for thorough results
Synergistic Formulas – Carefully balanced blends maximize FISTOQ effectiveness
Continuous Innovation – Ongoing development enhances FISTOQ capabilities
Future Innovations
Nanotech Integration – Advanced FISTOQ formulas Aptamer based
Smart Dispensing – Dispensing FISTOQ systems for optimal application
Customized Solutions – Tailored FISTOQ blends for specific industry needs
Enhanced Sustainability – Next-gen eco-friendly FISTOQ production methods